FLIP gamma/delta (AA 191-209), (C-Term) antibody

Catalog No. ABIN1734375

Product Details

Target: FLIP gamma/delta

Binding Specificity: AA 191-209, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Specificity: Reacts with the C-terminus part of human human FLIP gamma (35 kDa) and FLIP delta (25 kDa) but not FLIP alpha or FLIP beta.

Purification: Purified

Immunogen: Peptide corresponding to aa 191-209 at the C-terminus of human FLIPg /FLIP-S form (accession no. AAC51623).

Isotype: IgG

Application Details

Application Notes: Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only:
ICC1 μg/mL WB2 μg/mL

Positive control: HeLa cells

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute in PBS or medium which is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: Store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.

Expiry Date: 6 months

Target Details

Target: FLIP gamma/delta

Background: FLIP contains two death effector domains and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and -10 and potently inhibits apoptosis induced by death receptors CD95, DR3, TRAIL-R, and TNFR1. Four splice variants of FLIP have been identified and designated FLIP alpha, beta, gamma and delta.

CASP8 and FADD-like apoptosis regulator Caspase homolog, CASH Caspase-eight-related protein, Casper Caspase-like apoptosis regulatory protein, CLARP Cellular FLICE-like inhibitory protein, c-FLIP FADD-like antiapoptotic molecule 1, FLAME-1 Inhibitor of FLICE, I-FLICE MACH-related inducer of toxicity, MRIT Gene name: CFLAR, CASH, CASP8AP1, CLARP, MRIT

Gene ID: 8837

UniProt: O15519