MAPT antibody (N-Term)

Catalog No. ABIN1742569

This Rabbit Polyclonal antibody specifically detects MAPT in WB, IP, ICC and IHC (p). It exhibits reactivity toward Human, Rat and Mouse. It has been mentioned in 2+ publications

Quick Overview for MAPT antibody (N-Term) (ABIN1742569)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPT antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MAPT Antibody

Binding Specificity: N-Term

Purpose: Rabbit anti-Tau antibody

Specificity: Specific for tau.

Cross-Reactivity (Details): Reacts with: rat (P19332), mouse (P10637). Weaker signal: human (P10636). No signal: chicken. Other species not tested yet.

Purification: affinity purified

Immunogen: Recombinant protein corresponding to the N-terminal half of mouse Tau-D (UniProt Id: P10637-5)

Application Details

Application Notes: WB:1 : 1000 , IP:yes ICC:1 : 1000, IHC:not tested yet IHC-P:1 : 500,

Comment:

The antibody binds phosphorylated and non-phosphorylated tau proteins.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: For reconstitution add 50 μLH2O to get a 1 mg/mL solution in PBS.

Buffer: PBS. Albumin and azide were added for stabilization.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Storage: -20 °C,-80 °C,4 °C

Storage Comment: Antibodies should be stored at +4°C when still lyophilized. Then aliquot and store at -20°C to -80°C until use. Albumin and azide were added for stabilization. Do not freeze!

References for anti-MAPT antibody (ABIN1742569)

Schildknecht, Karreman, Pöltl, Efrémova, Kullmann, Gutbier, Krug, Scholz, Gerding, Leist: "Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases." in: ALTEX, Vol. 30, Issue 4, pp. 427-44, (2013) (PubMed).

Tong, Wong, Guttman, Ang, Forno, Shimadzu, Rajput, Muenter, Kish, Hornykiewicz, Furukawa: "Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation." in: Brain : a journal of neurology, Vol. 133, Issue Pt 1, pp. 172-88, (2010) (PubMed).

Target Details for MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Alternative Name: Tau

Background:

Synonyms: Microtubule-associated protein tau, Mapt, MAPT

Antigen Information: Tau is a neuronal microtubule associated protein

UniProt: P10637

Pathways: MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size