C1QA antibody

Catalog No. ABIN181104

Product Details anti-C1QA Antibody

Target: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This C1QA antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognises human complement component 1, q subcomponent (C1q), a 156 kDa secreted protein.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: Complement C1q, Complement 1q

Purification: Affinity Chromatography on Protein A.

Immunogen: Binds globular head domain of C1q, purified from human plasma. Genename: C1QA, C1QB, C1QC

Clone: 3R9-2

Isotype: IgG1

Application Details

Application Notes: ELISA. Flow Cytometry. Immunohistochemistry on Frozen Sections: It has been reported that this antibody worksvery well on acetone-fixed, frozen renal biopsies at a dilution of 1/500-1/600. Strongstaining was observed in the glomeruli and in some cases the peritubular capillary(potentially clinically significant). Recommended Positive Control: Kidney tissue from patients with streptococalglomerulonephritis.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Borate Buffered Saline, pH 8.4 containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for C1QA

Target: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Alternative Name: C1q A Subunit (C1QA Products)

Synonyms: zgc:109903 antibody, C1QA antibody, AI255395 antibody, C1q antibody, complement C1q A chain antibody, complement component 1, q subcomponent, A chain antibody, complement component 1, q subcomponent, alpha polypeptide antibody, C1QA antibody, c1qa antibody, C1qa antibody

Background: C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis.Synonyms: Complement 1q, Complement C1q

Gene ID: 712

UniProt: P02745

Pathways: Complement System