CLEC7A antibody

Catalog No. ABIN1820004

Product Details anti-CLEC7A Antibody

Target: CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CLEC7A antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Specificity: Recognizes human Dectin-1, also known as beta-glucan receptor (GR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (GR-A and GR-B) and several minor isoforms. GR-A and GR-B differs by the presence and absence, respectively, of a stalk region. The antibody (clone GE2) recognizes both of these isoforms. Clone GE2 could be used to inhibit receptor function.

Purification: Protein G purified

Endotoxin Level: Low Endotoxin

Immunogen: NIH3T3 cells expressing full length Beta-glucan receptor.

Clone: GE2

Isotype: IgG1

Application Details

Application Notes: Approved: Flo (1:1 - 1:25), Func

Usage: The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for CLEC7A

Target: CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))

Alternative Name: CLEC7A / Dectin 1 (CLEC7A Products)

Synonyms: CLEC7A antibody, BGR antibody, Clecsf12 antibody, beta-GR antibody, CANDF4 antibody, CLECSF12 antibody, DECTIN1 antibody, Clec7b antibody, RGD1565140 antibody, C-type lectin domain containing 7A antibody, C-type lectin domain family 7, member a antibody, CLEC7A antibody, Clec7a antibody

Background: Name/Gene ID: CLEC7A

Synonyms: CLEC7A, BGR, CANDF4, CLECSF12, Dectin-1, DC-associated C-type lectin 1, DECTIN1, HDectin-1, Beta-glucan receptor, Lectin-like receptor 1

Gene ID: 64581

Pathways: Activation of Innate immune Response