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CYP3A4 antibody
CYP3A4
Reactivity: Human
WB, ELISA, IHC, FACS, IF/ICC
Host: Mouse
Monoclonal
unconjugated
Product Details anti-CYP3A4 Antibody
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Target
See all CYP3A4 Antibodies
CYP3A4
(Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))
Reactivity
All reactivities for CYP3A4 antibodies
Human
Host
All hosts for CYP3A4 antibodies
Mouse
Clonality
All clonalities for CYP3A4 antibodies
Monoclonal
Conjugate
All conjugates for CYP3A4 antibodies
This CYP3A4 antibody is un-conjugated
Application
All applications for CYP3A4 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC)
Purification
Purified antibody
Immunogen
Purified recombinant fragment of human CYP3A4 expressed in E. Coli.
Isotype
IgG1
Top Product
Discover our top product CYP3A4 Primary Antibody
Alternatives
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anti-Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) (AA 18-120) antibody
CYP3A4
Reactivity: Human, Mouse, Rat
WB, FACS, IF (p), IHC (p), ICC, IF (cc), IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1.0 mg/mL
Buffer
PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Target Details for CYP3A4
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Target
CYP3A4
(Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))
Alternative Name
CYP3A4 (CYP3A4 Products )
Synonyms
CP33 antibody, CP34 antibody, CYP3A antibody, CYP3A3 antibody, CYPIIIA3 antibody, CYPIIIA4 antibody, HLP antibody, NF-25 antibody, P450C3 antibody, P450PCN1 antibody, MGC108372 antibody, CYP3A80 antibody, CYP3A4 antibody, CYP3A21 antibody, CYPIIIA21 antibody, CYP3A12 antibody, cytochrome P450 family 3 subfamily A member 4 antibody, cytochrome P450 family 3 subfamily A member 43 antibody, cytochrome P450 3A4 antibody, cytochrome P450, subfamily IIIA, polypeptide 4 antibody, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 antibody, cytochrome P450, family 3, subfamily A, polypeptide 4 antibody, CYP3A4 antibody, CYP3A43 antibody, PTRG_01782 antibody, PTRG_06060 antibody, cyp3a4 antibody
Background
This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist, however, it is now thought that this sequence represents a transcript variant of CYP3A4.
Molecular Weight
57.3 kDa
Gene ID
1576
UniProt
P08684
Pathways
Steroid Hormone Biosynthesis
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