This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This mouse p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T197 of mouse p27Kip1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Singh, Jatzek, Plisch, Srinivasan, Svaren, Suresh: "Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1." in: Molecular and cellular biology, Vol. 30, Issue 21, pp. 5145-59, (2010) (PubMed).
Antico-Arciuch, Dima, Liao, Refetoff, Di Cristofano: "Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females." in: Oncogene, Vol. 29, Issue 42, pp. 5678-86, (2010) (PubMed).
Mitsuhashi, Yonemoto, Sone, Kosuge, Kosaki, Takahashi: "In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 37, pp. 16331-5, (2010) (PubMed).
Zhang, Li, Yuan, Tian, Weidenfeld, Yang, Liu, Chokas, Morrisey: "Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms." in: Genes & development, Vol. 24, Issue 16, pp. 1746-57, (2010) (PubMed).
Wang, Li, Jiao, Zhang, Shao, Yuan, Yu: "RNA interference reveals a requirement for both p18INK4c and p27Kip1 in B lymphopoiesis." in: Journal of molecular cell biology, Vol. 2, Issue 4, pp. 209-16, (2010) (PubMed).
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].