Tuberin antibody (pThr1373)

Catalog No. ABIN1881935

There are 3+ publications for this product available. The Rabbit Polyclonal anti-Tuberin antibody is suitable to detect Tuberin in samples from Rat. It has been validated for DB.

Quick Overview for Tuberin antibody (pThr1373) (ABIN1881935)

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tuberin antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB41276

Product Details anti-Tuberin Antibody

Binding Specificity: pThr1373

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This rat TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1373 of rat TSC2.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Tuberin antibody (ABIN1881935)

Larson, Liu, Stevens, Li, Li, Evers, Gao: "Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1." in: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24987-98, (2010) (PubMed).

Di Nardo, Kramvis, Cho, Sadowski, Meikle, Kwiatkowski, Sahin: "Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 18, pp. 5926-37, (2009) (PubMed).

Shiono, Kobayashi, Takahashi, Sun, Abe, Zhang, Wang, Piao, Takagi, Mineki, Taka, Tada, Sonobe, Momose, Ueda, Hino: "The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition." in: Oncogene, Vol. 27, Issue 52, pp. 6690-7, (2008) (PubMed).

Target Details for Tuberin

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Alternative Name: TSC2

Background: Acts as a tumor suppressor, may play a role in cell cycle regulation, acute phase response, and negative regulation of cell proliferation [RGD].

Molecular Weight: 201278

NCBI Accession: NP_036812

UniProt: P49816

Pathways: RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus