RPS6KA6 antibody (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6) (AA 15-45)

Details for Product anti-RPS6KA6 Antibody No. ABIN1882127, Supplier: Log in to see
Antigen
  • 2610524K04Rik
  • RSK4
  • PP90RSK4
  • rps6ka6
  • wu:fj94b02
  • zgc:66139
  • ribosomal protein S6 kinase polypeptide 6
  • ribosomal protein S6 kinase A6
  • ribosomal protein S6 kinase a, like
  • Rps6ka6
  • RPS6KA6
  • rps6kal
Alternatives
anti-Human RPS6KA6 antibody for Western Blotting
Epitope
AA 15-45, N-Term
10
9
5
4
4
2
2
1
Reactivity
Human, Monkey
42
5
5
2
Host
Rabbit
23
17
2
Clonality (Clone)
Polyclonal ()
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
37
23
18
13
6
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen This RSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human RSK4.
Clone RB0894
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name RSK4 (RPS6KA6 Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK). The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).

Synonyms: RPS6KA6, RSK4, Ribosomal protein S6 kinase alpha-6, 90 kDa ribosomal protein S6 kinase 6, Ribosomal S6 kinase 4, pp90RSK4
NCBI Accession NP_055311
UniProt Q9UK32
Pathways MAPK Signaling
Application Notes WB: 1:1000,IHC (p): 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6) (AA 15-45), (N-Term) antibody (ABIN1882127) RSK4 Antibody (N-term) (ABIN1882127) is used to detect RSK4 in 7 different cell lines...
Western Blotting (WB) image for anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6) (AA 15-45), (N-Term) antibody (ABIN1882127) RSK4 Antibody (N-term) (ABIN1882127) is used to detect RSK4 in 7 different cell lines...
Product cited in: Thakur, Sun, Bollig, Wu, Biliran, Banerjee, Sarkar, Liao: "Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 14, pp. 4427-36, 2008 (PubMed).

Yntema, van den Helm, Kissing, van Duijnhoven, Poppelaars, Chelly, Moraine, Fryns, Hamel, Heilbronner, Pander, Brunner, Ropers, Cremers, van Bokhoven: "A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation." in: Genomics, Vol. 62, Issue 3, pp. 332-43, 2000 (PubMed).

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