The protein encoded by this gene is a member of the tripartite motif (TRIM) family.The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins.Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site.The protein localizes to lysosomes and the Golgi apparatus.It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation.Three alternatively spliced transcript variants for this gene have been described.[provided by RefSeq] Synonyms: ARD1, ARFD1, RNF46