SMC1A antibody (AA 1-218)

Catalog No. ABIN1885793

Product Details anti-SMC1A Antibody

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Binding Specificity: AA 1-218

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 218 of SMC1A

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for SMC1A

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Alternative Name: SMC1A (SMC1A Products)

Synonyms: CDLS2 antibody, DXS423E antibody, SB1.8 antibody, SMC1 antibody, SMC1L1 antibody, SMC1alpha antibody, SMCB antibody, SMC-1A antibody, NV15570 antibody, 5830426I24Rik antibody, Sb1.8 antibody, Smc1 antibody, Smc1alpha antibody, Smc1l1 antibody, Smcb antibody, mKIAA0178 antibody, smc1 antibody, smc1a antibody, smc1l1 antibody, xSMC1 antibody, smc1aa antibody, structural maintenance of chromosomes 1A antibody, structural maintenance of chromosomes 1A b antibody, structural maintenance of chromosomes 1A L homeolog antibody, SMC1A antibody, smc1a antibody, Smc1a antibody, smc1ab antibody, smc1a.L antibody

Background: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division.The cohesin multiprotein complex is required for sister chromatid cohesion.This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene.Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain.Therefore, the encoded protein is thought to be an important part of functional kinetochores.In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair.This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.[provided by RefSeq]

Molecular Weight: 143 kDa

Gene ID: 8243

NCBI Accession: NP_006297, NM_006306

Pathways: Stem Cell Maintenance