Caspase 4 antibody (AA 68-132)

Catalog No. ABIN1886611

This Rabbit Polyclonal antibody specifically detects Caspase 4 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for Caspase 4 antibody (AA 68-132) (ABIN1886611)

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Caspase 4 Antibody

Binding Specificity: AA 68-132

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 68 and 132 of caspase-4

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 1 x PBS, 1 % BSA, 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for Caspase 4

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Alternative Name: caspase-4

Background: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit.Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits.This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor.When overexpressed, this gene induces cell apoptosis.Alternative splicing results in transcript variants encoding distinct isoforms.[provided by RefSeq]

Molecular Weight: 43 kDa

Gene ID: 837

NCBI Accession: NP_001216, NM_001225

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity