Renin in Preproprotein (AA 70-302) antibody
Reactivity: Human
IHC, WB
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Renin in Preproprotein
- Binding Specificity
- AA 70-302
- Reactivity
- Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 70 and 302 of Human REN
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- Application Notes
-
Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250 - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- Biohazard Informations: This product contains thimerosal which is hazardous.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Target
- Renin in Preproprotein
- Background
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Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure.Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance.Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined.Mutations in this gene have been shown to cause familial hyperproreninemia.[provided by RefSeq]
Synonyms: FLJ10761 - Molecular Weight
- 45 kDa
- Gene ID
- 5972
- NCBI Accession
- NP_000528, NM_000537
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