TMEM59L
Reactivity: Human
WB, IF (p), IF (cc)
Host: Rabbit
Polyclonal
Alexa Fluor 488
Restrictions
For Research Use only
Format
Liquid
Buffer
PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice
Avoid freezing and thawing repeatly.
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
LOC719572 antibody, BSMAP antibody, C19orf4 antibody, 5330410G16Rik antibody, RGD1305557 antibody, transmembrane protein 59 like antibody, transmembrane protein 59-like antibody, TMEM59L antibody, Tmem59l antibody
Background
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis.TMEM59L is a type I membrane glycoprotein that is expressed in the brain.A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding. Synonyms: Transmembrane protein 59L, brain-specific membrane-anchored protein, BSMAP