NPAS3 antibody (Center)

Catalog No. ABIN1887738

Product Details anti-NPAS3 Antibody

Target: NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPAS3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 28 amino acid peptide from near the center of human NPAS3.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for NPAS3

Target: NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))

Alternative Name: NPAS3 (NPAS3 Products)

Synonyms: trh antibody, mop6 antibody, pasd6 antibody, MGC145768 antibody, MOP6 antibody, PASD6 antibody, bHLHe12 antibody, 4930423H22Rik antibody, neuronal PAS domain protein 3 antibody, npas3 antibody, NPAS3 antibody, Npas3 antibody

Background: Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia.It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region.NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities.Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin.These results demonstrate the essential role played by NPAS3 during structural and functional brain development.At least three isoforms of NPAS3 are known to exist.
Synonyms: Neuronal PAS domain-containing protein 3, member of Pas protein 6, MOP6

UniProt: Q8IXF0