SLC39A1
Reactivity: Human
Host: Rabbit
Polyclonal
FITC
Restrictions
For Research Use only
Format
Liquid
Buffer
PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice
Avoid freezing and thawing repeatly.
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
Target
SLC39A1
(Solute Carrier Family 39 (Zinc Transporter), Member 1 (SLC39A1))
cb629 antibody, DrZIP1 antibody, sb:cb629 antibody, zgc:111852 antibody, frzip1p antibody, zip1 antibody, zirtl antibody, ZIP1 antibody, ZIRTL antibody, Zip1 antibody, Zirtl antibody, solute carrier family 39 (zinc transporter), member 1 antibody, solute carrier family 39 member 1 antibody, solute carrier family 39 member 1 L homeolog antibody, slc39a1 antibody, Slc39a1 antibody, SLC39A1 antibody, slc39a1.L antibody
Background
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters.Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation.ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer.More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappaB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo. Synonyms: Solute carrier family 39 member A1, Slc39A1, ZIRTL