SYNPO2 antibody (N-Term)
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- Target See all SYNPO2 Antibodies
- SYNPO2 (Synaptopodin 2 (SYNPO2))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SYNPO2 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- 20 amino acid peptide near the amino terminus of human SYNPO2.
- Top Product
- Discover our top product SYNPO2 Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- Handling Advice
- Avoid freezing and thawing repeatly.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- Target
- SYNPO2 (Synaptopodin 2 (SYNPO2))
- Alternative Name
- SYNPO2 (SYNPO2 Products)
- Synonyms
- SYNOP2 antibody, RGD1564779 antibody, 1110069I04Rik antibody, 2310068J10Rik antibody, 9530006G20Rik antibody, AI848603 antibody, Myo antibody, synaptopodin 2 antibody, synaptopodin-2 antibody, SYNPO2 antibody, LOC100484043 antibody, Synpo2 antibody
- Background
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SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs.It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein.SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton.While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.
Synonyms: Synaptopodin 2, myopodin - NCBI Accession
- NP_597734
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