CXXC4 antibody (N-Term)

Catalog No. ABIN1888157

Product Details anti-CXXC4 Antibody

Target: CXXC4 (CXXC Finger Protein 4 (CXXC4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXXC4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: CXXC4 antibody was raised against an 18 amino acid peptide near the amino terminus of human CXXC4.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for CXXC4

Target: CXXC4 (CXXC Finger Protein 4 (CXXC4))

Alternative Name: CXXC4 (CXXC4 Products)

Synonyms: 9330210J02Rik antibody, C030003J12Rik antibody, Idax antibody, IDAX antibody, Xldax antibody, xIdax antibody, CXXC finger 4 antibody, CXXC finger protein 4 antibody, CXXC finger protein 4 S homeolog antibody, Cxxc4 antibody, CXXC4 antibody, cxxc4.S antibody

Background: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region.CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN.In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin.Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
Synonyms: CXXC-type zinc finger protein 4, IDAX

NCBI Accession: NP_079488