At least three isoforms of TM4SF1 are known to exist, this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.
Purification
Affinity chromatography purified via peptide column
Immunogen
TM4SF1 antibody was raised against an 18 amino acid peptide near the amino terminus of human TM4SF1.
TM4SF1
Reactivity: Human
IF (cc), IF (p)
Host: Rabbit
Polyclonal
Alexa Fluor 488
Restrictions
For Research Use only
Format
Liquid
Buffer
PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice
Avoid freezing and thawing repeatly.
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
Target
TM4SF1
(Transmembrane 4 L Six Family Member 1 (TM4SF1))
MGC85546 antibody, h-l6 antibody, m3s1 antibody, taal6 antibody, H-L6 antibody, L6 antibody, M3S1 antibody, TAAL6 antibody, MM3 antibody, M3s1 antibody, transmembrane 4 L six family member 1 antibody, transmembrane 4 L six family member 1 S homeolog antibody, transmembrane 4 superfamily member 1 antibody, TM4SF1 antibody, tm4sf1.S antibody, tm4sf1 antibody, Tm4sf1 antibody
Background
TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers.Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy. Synonyms: Transmembrane 4 L6 family member 1, L6, H-L6, M3S1, TAAL6