SYNCRIP antibody

Catalog No. ABIN1944935

Product Details anti-SYNCRIP Antibody

Target: SYNCRIP (Synaptotagmin Binding, Cytoplasmic RNA Interacting Protein (SYNCRIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYNCRIP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Isotype: IgG

Application Details

Application Notes: IF: 1:100. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-SYNCRIP antibody (ABIN1944935)

Mourelatos, Abel, Yong, Kataoka, Dreyfuss: "SMN interacts with a novel family of hnRNP and spliceosomal proteins." in: The EMBO journal, Vol. 20, Issue 19, pp. 5443-52, (2001) (PubMed).

Harris, Boden, Astell: "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice." in: Journal of virology, Vol. 73, Issue 1, pp. 72-80, (1999) (PubMed).

Target Details for SYNCRIP

Target: SYNCRIP (Synaptotagmin Binding, Cytoplasmic RNA Interacting Protein (SYNCRIP))

Alternative Name: hnRNP Q (SYNCRIP Products)

Synonyms: GRY-RBP antibody, GRYRBP antibody, HNRNPQ antibody, HNRPQ1 antibody, NSAP1 antibody, PP68 antibody, hnRNP-Q antibody, 2610109K23Rik antibody, 4632417O19Rik antibody, Nsap1 antibody, Nsap1l antibody, pp68 antibody, nsap1 antibody, wu:fe02c03 antibody, wu:fe47h09 antibody, SYNCRIP antibody, hnrpq1 antibody, gry-rbp antibody, rp1-3j17.2 antibody, synaptotagmin binding cytoplasmic RNA interacting protein antibody, synaptotagmin binding, cytoplasmic RNA interacting protein antibody, synaptotagmin binding cytoplasmic RNA interacting protein S homeolog antibody, SYNCRIP antibody, Syncrip antibody, syncrip antibody, syncrip.S antibody

Background: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD- mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma- induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation, seems not to be essential for GAIT complex function.

Molecular Weight: 69603 Da

Gene ID: 10492

UniProt: O60506