CDK4 antibody (AA 2-303) (FITC)

Catalog No. ABIN1991942

The Rabbit Polyclonal anti-CDK4 antibody has been validated for WB and ELISA. It is suitable to detect CDK4 in samples from Human.

Quick Overview for CDK4 antibody (AA 2-303) (FITC) (ABIN1991942)

Target: CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK4 antibody is conjugated to FITC

Application: Western Blotting (WB), ELISA

Product Details anti-CDK4 Antibody (FITC)

Binding Specificity: AA 2-303

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cyclin-dependent kinase 4 protein (2-303AA)

Isotype: IgG

Application Details

Application Notes: Optimal working concentration should be determinde by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CDK4

Target: CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Alternative Name: CDK4

Background:

Background: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Aliases: Cdk 4 antibody, cdk4 antibody, CDK4 protein antibody, CDK4_HUMAN antibody, Cell division kinase 4 antibody, Cell division protein kinase 4 antibody, CMM 3 antibody, CMM3 antibody, Crk3 antibody, Cyclin dependent kinase 4 antibody, Cyclin-dependent kinase 4 antibody, Melanoma cutaneous malignant 3 antibody, MGC14458 antibody, p34 cdk4 antibody, PSK J3 antibody, PSK-J3 antibody

UniProt: P11802

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size