CNTNAP2 antibody (C-Term)

Catalog No. ABIN2017587

Product Details anti-CNTNAP2 Antibody

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNTNAP2 antibody is un-conjugated

Application: Please inquire

Specificity: Rabbit Anti-Caspr2 Polyclonal Antibody detects endogenous levels of mouse and rat Caspr2.

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Cross-Reactivity (Details): It is predicted to react with human Caspr2 according to sequence homology.
This product has not been tested for other species yet.

Characteristics: Rabbit Anti-Caspr2 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Caspr2 (Swiss Prot: Q9UHC6).

Purification: Immunoaffinity chromatography

Immunogen: KLH-coupled synthetic peptide from C-terminal of human Caspr2.

Isotype: IgG

Application Details

Comment:

Positive Control: mouse brain and rat brain.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/mL.

Concentration: 0.5 mg/mL

Buffer: Lyophilized with PBS, pH 7.4, containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing cycles.

Storage: 4 °C/-20 °C

Storage Comment: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below.

References for anti-CNTNAP2 antibody (ABIN2017587)

Chen, Koopmans, Gordon, Paliukhovich, Klaassen, van der Schors, Peles, Verhage, Smit, Li: "Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes." in: Biochimica et biophysica acta, Vol. 1854, Issue 7, pp. 827-33, (2015) (PubMed).

Target Details for CNTNAP2

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Alternative Name: Caspr2 (CNTNAP2 Products)

Synonyms: AUTS15 antibody, CASPR2 antibody, CDFE antibody, NRXN4 antibody, PTHSL1 antibody, 5430425M22Rik antibody, Caspr2 antibody, mKIAA0868 antibody, CASPR antibody, MGC145769 antibody, MGC147944 antibody, MGC147981 antibody, contactin associated protein like 2 antibody, contactin associated protein-like 2 antibody, contactin associated protein like 2b antibody, CNTNAP2 antibody, Cntnap2 antibody, cntnap2b antibody, cntnap2 antibody

Background: Contacting-associated protein 2 (Caspr2) is a member of the neurexin superfamily that mediates nervous system cell-cell interactions. The C-terminal region of Caspr2 participates in the association with Kv1.1, Kv1.2 and their Kv-beta-2 subunit. Expression of Caspr2 is regulated directly by transcription factor FOXP2. Disruption or decreased expression of Caspr2 probably leads to a disturbed distribution of potassium channels in the nervous system. Mutations in the Caspr2 gene have been linked to many diseases such as focal epilepsy, autism spectrum disorder and cortical dysplasia-focal epilepsy syndrome (CDFES).

UniProt: Q9UHC6