BRIP1 antibody (pSer990) (HRP)

Catalog No. ABIN2170685

Product Details anti-BRIP1 Antibody (HRP)

Target: BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1))

Binding Specificity: pSer990

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRIP1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This phosphorylation site is homologous to that of Ser921 in Bovine.

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human BRIP1 around the phosphorylation site of Ser990

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BRIP1

Target: BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1))

Alternative Name: BRIP1 (BRIP1 Products)

Synonyms: MGC68622 antibody, BRIP1 antibody, fancj antibody, si:ch211-158l18.1 antibody, BACH1 antibody, FANCJ antibody, OF antibody, 3110009N10Rik antibody, 8030460J03Rik antibody, Bach1 antibody, FACJ antibody, Fancj antibody, BRCA1 interacting protein C-terminal helicase 1 antibody, BRCA1 interacting protein C-terminal helicase 1 L homeolog antibody, Brip1 antibody, brip1.L antibody, BRIP1 antibody, brip1 antibody

Background:

Synonyms: OF, BACH1, FANCJ, Fanconi anemia group J protein, Protein FACJ, ATP-dependent RNA helicase BRIP1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein C-terminal helicase 1, BRCA1-interacting protein 1, BRIP1

Background: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.

Gene ID: 83990

UniProt: Q9BX63

Pathways: DNA Damage Repair