MAP2K3 antibody (pSer207)
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- Target See all MAP2K3 Antibodies
- MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
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Binding Specificity
- pSer207
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MAP2K3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- This phosphorylation site is homologous in Mouse and homologous to that of Ser290 in Rat in MKK3, and homologous across the listed species in MKK6.
- Cross-Reactivity
- Human, Mouse, Rat
- Predicted Reactivity
- Dog,Cow,Pig,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human MKK3 around the phosphorylation site of Ser218
- Isotype
- IgG
- Top Product
- Discover our top product MAP2K3 Primary Antibody
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
- Alternative Name
- MKK3 + MKK6 (MAP2K3 Products)
- Synonyms
- MAPKK3 antibody, MEK3 antibody, MKK3 antibody, PRKMK3 antibody, SAPKK-2 antibody, SAPKK2 antibody, AW212142 antibody, Prkmk3 antibody, mMKK3b antibody, Mkk3 antibody, mitogen-activated protein kinase kinase 3 antibody, mitogen activated protein kinase kinase 3 antibody, MAP kinase activator XMEK3 antibody, MAP2K3 antibody, Map2k3 antibody, map2k3 antibody
- Background
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Synonyms: MKK3Ser218, MAP Kinase Kinase 3, Dual specicity mitogen activated protein kinase kinase 3, ERK kinase 3, MAP kinase kinase 3, MAP2K 3, MAPK ERK kinase 3, MAPK kinase 3, MAPKK 3, MAPKK3, MEK 3, MEK3, Mitogen activated protein kinase kinase 3, MKK 3, MKK3, mMKK 3b, mMKK3b, MPK 3, PRKMK 3, PRKMK3, Protein kinase mitogen activated kinase 3, SKK2, zMKK 3, MP2K3_HUMAN, MP2K6_HUMAN
Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
- Gene ID
- 5606, 5608
- Pathways
- MAPK Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2
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