DcR1 antibody (FITC)
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- Target See all DcR1 (TNFRSF10C) Antibodies
- DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This DcR1 antibody is conjugated to FITC
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- Specificity
- Recognizes human CD263, a 60 Kd cell surface protein, which is otherwise known as decoy receptor 1 (DcR1). CD263 is a member of the tumor necrosis factor (TNF) receptor superfamily that binds to TNF-related apoptosis inducing ligand (TRAIL). As the receptor does not possess cytoplasmic death domains it cannot induce apoptosis, but instead plays an important role in inhibiting TRAIL-induced apoptosis. CD263 is expressed in normal tissues including heart, skeletal tissues and peripheral blood neutrophils, but weakly expressed in tumor cells. The 2B8 antibody does not inhibit DcR1 (CD263) inhibitory function in TRAIL-induced apoptosis.
- Purification
- Protein G purified
- Immunogen
- DcR1-Fc Chimeric protein.
- Isotype
- IgG1
- Top Product
- Discover our top product TNFRSF10C Primary Antibody
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- Application Notes
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Approved: Flo (1:1 - 1:10), IP
Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request. - Comment
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4, 0.09 % sodium azide, 1 % BSA.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Target
- DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
- Alternative Name
- TNFRSF10C / TRAIL-R3 / DCR1 (TNFRSF10C Products)
- Synonyms
- CD263 antibody, DCR1 antibody, DCR1-TNFR antibody, LIT antibody, TRAIL-R3 antibody, TRAILR3 antibody, TRID antibody, TNFRSF10C antibody, TNF receptor superfamily member 10c antibody, TNFRSF10C antibody
- Background
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Name/Gene ID: TNFRSF10C
Family: TNF Receptor
Synonyms: TNFRSF10C, CD263 antigen, CD263, Cytotoxic TRAIL receptor-3, Decoy receptor 1, DCR1, DCR1-TNFR, LIT, Lymphocyte inhibitor of TRAIL, TRAIL-R3, TRAILR3, TRAIL receptor 3, TRID - Gene ID
- 8794
- Pathways
- Apoptosis
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