CDKN2AIP antibody
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- Target See all CDKN2AIP Antibodies
- CDKN2AIP (CDKN2A Interacting Protein (CDKN2AIP))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CDKN2AIP antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human CDKN2AIP
- Isotype
- IgG
- Top Product
- Discover our top product CDKN2AIP Primary Antibody
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- Application Notes
- IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.3 mg/mL
- Buffer
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
- Preservative
- Sodium azide
- Handling Advice
- Avoid freeze / thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- CDKN2AIP (CDKN2A Interacting Protein (CDKN2AIP))
- Alternative Name
- CDKN2AIP (CDKN2AIP Products)
- Synonyms
- CARF antibody, 4921511I16Rik antibody, AW208986 antibody, CDKN2AIP antibody, RGD1305302 antibody, CDKN2A interacting protein antibody, CDKN2A interacting protein L homeolog antibody, CDKN2AIP antibody, Cdkn2aip antibody, cdkn2aip antibody, cdkn2aip.L antibody
- Background
- CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.
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