ACTH receptor,ACTH-R,ACTHR,ACTHR,Adrenocorticotropic hormone receptor,Adrenocorticotropin receptor,Corticotropin receptor,MC2 receptor,MC2-R,MC2R,Melanocortin 2 receptor (adrenocorticotropic hormone),Melanocortin 2 receptor,Melanocortin receptor 2,MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.