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DAB2 antibody
DAB2
Reactivity: Human, Mouse, Rat
WB, ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-DAB2 Antibody
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Target
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DAB2
(Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
Reactivity
All reactivities for DAB2 antibodies
Human, Mouse, Rat
Host
All hosts for DAB2 antibodies
Rabbit
Clonality
All clonalities for DAB2 antibodies
Polyclonal
Conjugate
All conjugates for DAB2 antibodies
This DAB2 antibody is un-conjugated
Application
All applications for DAB2 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Purification
Affinity purification
Immunogen
Recombinant protein of human DAB2
Isotype
IgG
Top Product
Discover our top product DAB2 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB 1:500-1:2000, IHC 1:50-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.6 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Preservative
Sodium azide
Handling Advice
Avoid freeze / thaw cycles.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for DAB2
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Target
DAB2
(Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
Alternative Name
DAB2 (DAB2 Products )
Synonyms
DOC-2 antibody, DOC2 antibody, 5730435J12Rik antibody, AA960054 antibody, AI957090 antibody, D15Wsu122e antibody, D630005B22Rik antibody, Doc-2 antibody, Doc2 antibody, p96 antibody, DAB2, clathrin adaptor protein antibody, disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) antibody, Dab, mitogen-responsive phosphoprotein, homolog 2 antibody, disabled 2, mitogen-responsive phosphoprotein antibody, DAB2 antibody, dab2 antibody, Dab2 antibody
Background
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Molecular Weight
Calculated MW: 82 kDa
Pathways
Intracellular Steroid Hormone Receptor Signaling Pathway , Regulation of Intracellular Steroid Hormone Receptor Signaling , Regulation of Hormone Metabolic Process , Regulation of Hormone Biosynthetic Process
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