KPNA4 antibody (full length)

Catalog No. ABIN2452037

There are 3+ publications for this product available. The Rat Monoclonal anti-KPNA4 antibody is suitable to detect KPNA4 in samples from Mouse. It has been validated for WB and ELISA.

Quick Overview for KPNA4 antibody (full length) (ABIN2452037)

Target: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This KPNA4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 3D10

Product Details anti-KPNA4 Antibody

Binding Specificity: full length

Specificity: Reactive with human, simian, mouse, rat, hamster, canine and bovine importin a3. This antibody doesn't recognize other importin a family including a4.

Characteristics: The antibody was purified from the serum-free cultured medium of the hybridoma under mild conditions by proprietary chromatography processes.

Purification: Purified

Sterility: Sterile filtered

Immunogen: Recombinant mouse importin a3 /KPNA4/ Qip 1 (full length)

Isotype: IgG2a kappa

Application Details

Application Notes: 1. Western blotting: 250~500 fold dilution
2. ELISA
This antibody doesn't work for immunostaining and immunoprecipitation.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Preservative: Azide free

Storage: -20 °C/-80 °C

Storage Comment: -20 C (For long term storage: -70 C)

References for anti-KPNA4 antibody (ABIN2452037)

Yasuhara, Shibazaki, Tanaka, Nagai, Kamikawa, Oe, Asally, Kamachi, Kondoh, Yoneda: "Triggering neural differentiation of ES cells by subtype switching of importin-alpha." in: Nature cell biology, Vol. 9, Issue 1, pp. 72-9, (2007) (PubMed).

Yoneda: "Nucleocytoplasmic protein traffic and its significance to cell function." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 5, Issue 10, pp. 777-87, (2000) (PubMed).

Miyamoto, Imamoto, Sekimoto, Tachibana, Seki, Tada, Enomoto, Yoneda: "Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors." in: The Journal of biological chemistry, Vol. 272, Issue 42, pp. 26375-81, (1997) (PubMed).

Target Details for KPNA4

Target: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Alternative Name: Importin alpha 3 / Qip1KPNA4

Background: Importin a proteins play a pivotal role in the import of proteins from the cytoplasm to the nucleus. Importin a proteins shuttle between nucleus and cytoplasm, bind nuclear localization signal (NLS)-bearing proteins, and mediate the protein import into the nucleus with importin b. Several importin a isotypes have been identified, each exhibiting differential recognition and nuclear transport, probably via preferential binding to a particular NLS. The importin a3 (KPNA4, Qip1) is a member of the importin a family of proteins belonging to the Qip1 subfamily.

Pathways: Protein targeting to Nucleus