FBXW2 antibody

Catalog No. ABIN2458706

Product Details anti-FBXW2 Antibody

Target: FBXW2 (F-Box and WD Repeat Domain Containing 2 (FBXW2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human FBXW2.

Application Details

Application Notes: FBXW2 antibody can be used for detection of FBXW2 by ELISA at 1:1562500. FBXW2 antibody can be used for detection of FBXW2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store FBXW2 antibody at -20 °C.

Target Details for FBXW2

Target: FBXW2 (F-Box and WD Repeat Domain Containing 2 (FBXW2))

Alternative Name: FBXW2 (FBXW2 Products)

Synonyms: FBXW2 antibody, md6 antibody, fbw2 antibody, fwd2 antibody, MGC53244 antibody, FBW2 antibody, Fwd2 antibody, Md6 antibody, wu:fc72f10 antibody, zgc:110365 antibody, 2700071L08Rik antibody, MD6 antibody, F-box and WD repeat domain containing 2 antibody, F-box and WD repeat domain containing 2 L homeolog antibody, F-box and WD-40 domain protein 2 antibody, FBXW2 antibody, fbxw2 antibody, Fbxw2 antibody, fbxw2.L antibody

Background: F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. FBXW2 is the second identified member of the F-box family and contains multiple WD-40 repeats.F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.

Molecular Weight: 51 kDa

Gene ID: 26190

NCBI Accession: NP_036296

UniProt: Q9UKT8