GMP Synthase antibody

Catalog No. ABIN2459212

Product Details anti-GMP Synthase Antibody

Target: GMP Synthase (GMPS) (Guanine Monophosphate Synthetase (GMPS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GMP Synthase antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GMPS.

Application Details

Application Notes: GMPS antibody can be used for detection of GMPS by ELISA at 1:312500. GMPS antibody can be used for detection of GMPS by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store GMPS antibody at -20 °C.

Target Details for GMP Synthase

Target: GMP Synthase (GMPS) (Guanine Monophosphate Synthetase (GMPS))

Alternative Name: GMPS (GMPS Products)

Synonyms: GMPS antibody, AA591640 antibody, AI047208 antibody, sb:cb632 antibody, wu:fb76b01 antibody, wu:fi05a09 antibody, zgc:66002 antibody, guanine monophosphate synthase antibody, guanine monophosphate synthase L homeolog antibody, guanine monophosphate synthetase antibody, GMPS antibody, gmps.L antibody, gmps antibody, Gmps antibody

Background: In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.

Molecular Weight: 77 kDa

Gene ID: 8833

NCBI Accession: NP_003866

UniProt: P49915

Pathways: Ribonucleoside Biosynthetic Process