T-Box 1 antibody

Catalog No. ABIN2460712

Product Details anti-T-Box 1 Antibody

Target: T-Box 1 (TBX1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TBX1.

Application Details

Application Notes: TBX1 antibody can be used for detection of TBX1 by ELISA at 1:62500. TBX1 antibody can be used for detection of TBX1 by western blot at 5.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store TBX1 antibody at -20 °C.

Target Details for T-Box 1

Target: T-Box 1 (TBX1)

Alternative Name: TBX1 (TBX1 Products)

Synonyms: CAFS antibody, CTHM antibody, DGCR antibody, DGS antibody, DORV antibody, TBX1C antibody, TGA antibody, VCFS antibody, mp:zf637-3-000616 antibody, zgc:136724 antibody, TBX1 antibody, dgs antibody, tga antibody, cafs antibody, cthm antibody, dgcr antibody, dorv antibody, vcfs antibody, tbx1c antibody, xtbx1 antibody, tbx1 antibody, T-box 1 antibody, T-box 1 S homeolog antibody, T-box 1 L homeolog antibody, TBX1 antibody, Tbx1 antibody, tbx1 antibody, tbx1.S antibody, tbx1.L antibody

Background: TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX1 product shares 98 % amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where TBX1 has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 53 kDa

Gene ID: 6899

NCBI Accession: NP_542378

Pathways: Retinoic Acid Receptor Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation