SUZ12 antibody

Catalog No. ABIN2461868

Product Details anti-SUZ12 Antibody

Target: SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUZ12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SUZ12.

Application Details

Application Notes: SUZ12 antibody can be used for detection of SUZ12 by ELISA at 1:312500. SUZ12 antibody can be used for detection of SUZ12 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SUZ12 antibody at -20 °C.

Target Details for SUZ12

Target: SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))

Alternative Name: SUZ12 (SUZ12 Products)

Synonyms: fc31h10 antibody, im:7153578 antibody, si:dkey-10p5.2 antibody, suz12 antibody, wu:fc31h10 antibody, 2610028O16Rik antibody, AI195385 antibody, AU016842 antibody, AW536442 antibody, D11Ertd530e antibody, mKIAA0160 antibody, Xsuz12 antibody, chet9 antibody, jjaz1 antibody, CHET9 antibody, ChET 9 protein antibody, JJAZ1 antibody, suz12l antibody, zgc:100863 antibody, SUZ12 polycomb repressive complex 2b subunit antibody, SUZ12 polycomb repressive complex 2 subunit antibody, suppressor of zeste 12 homolog (Drosophila) antibody, SUZ12 polycomb repressive complex 2 subunit S homeolog antibody, SUZ12 polycomb repressive complex 2a subunit antibody, suz12b antibody, Suz12 antibody, SUZ12 antibody, suz12.S antibody, suz12a antibody

Background: A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t (7,17) (p15,q21) with JAZF1 generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molecular Weight: 83 kDa

Gene ID: 23512

NCBI Accession: NP_056170

UniProt: Q15022