COPA antibody

Catalog No. ABIN2463478

Product Details anti-COPA Antibody

Target: COPA (Coatomer Protein Complex, Subunit alpha (COPA))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPA antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COPA.

Application Details

Application Notes: COPA antibody can be used for detection of COPA by ELISA at 1:62500. COPA antibody can be used for detection of COPA by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store COPA antibody at -20 °C.

Target Details for COPA

Target: COPA (Coatomer Protein Complex, Subunit alpha (COPA))

Alternative Name: COPA (COPA Products)

Synonyms: COPA antibody, DDBDRAFT_0189693 antibody, DDBDRAFT_0233797 antibody, DDB_0189693 antibody, DDB_0233797 antibody, DKFZp469O221 antibody, AU040324 antibody, xenin antibody, HEP-COP antibody, cb281 antibody, fb13c12 antibody, wu:fb13c12 antibody, coatomer protein complex subunit alpha antibody, WD40 repeat-containing protein antibody, Coatomer subunit alpha antibody, coatomer protein complex, subunit alpha antibody, coatomer protein complex subunit alpha L homeolog antibody, COPA antibody, copA antibody, cgd8_860 antibody, Chro.80105 antibody, AFUA_3G08840 antibody, copa antibody, Copa antibody, copa.L antibody

Background: In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone.In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.

Molecular Weight: 135 kDa

Gene ID: 1314

NCBI Accession: NP_004362

UniProt: P53621

Pathways: Hormone Activity