ADRA2B antibody (AA 200-299)

Catalog No. ABIN2467937

Product Details anti-ADRA2B Antibody

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Binding Specificity: AA 200-299

Reactivity: Human

Host: Chicken

Clonality: Polyclonal

Conjugate: This ADRA2B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Immunoaffinity Purified

Application Details

Application Notes: alpha-2B adrenergic receptor antibody can be used for the detection of alpha-2B adrenergic receptor by Western Blot.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Preservative: Without preservative

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Storage Comment: ADRA2B antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Target Details for ADRA2B

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Alternative Name: ADRA2B (ADRA2B Products)

Synonyms: ADRA2L1 antibody, ADRA2RL1 antibody, ADRARL1 antibody, ALPHA2BAR antibody, alpha-2BAR antibody, Adra-2b antibody, [a]2B antibody, alpha2-C2 antibody, alpha2B antibody, ADRA2B antibody, zgc:194747 antibody, Adra2b antibody, adrenoceptor alpha 2B antibody, adrenergic receptor, alpha 2b antibody, adrenergic, alpha-2B-, receptor antibody, adrenoceptor alpha 2C antibody, ADRA2B antibody, Adra2b antibody, ADRA2C antibody, adra2b antibody

Background: FUNCTION: alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

SUMMARY: alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This protein is the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This protein contains no introns in either its coding or untranslated sequences.

Molecular Weight: 50 kDa (calculated)

Gene ID: 151

NCBI Accession: NP_000673

UniProt: P18089

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process