Insulin Receptor antibody (Internal Region)

Catalog No. ABIN2469537

This anti-Insulin Receptor antibody is a Rabbit Polyclonal antibody detecting Insulin Receptor in IHC. Suitable for Human, Monkey, Gibbon and Gorilla.

Quick Overview for Insulin Receptor antibody (Internal Region) (ABIN2469537)

Target: Insulin Receptor (INSR)

Reactivity: Human, Monkey, Gibbon, Gorilla

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Insulin Receptor antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Insulin Receptor Antibody

Binding Specificity: Internal Region

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins, except JARID2 (69 % ).

Purification: Immunoaffinity Chromatography

Immunogen: Insulin Receptor antibody was raised against a peptide located near the internal domain of Insulin Receptor (Human).

Application Details

Application Notes: Insulin Receptor antibody can be used in ELISA starting at 1:10000, and immunohistochemistry starting at 1:200 - 1:400.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: Insulin Receptor antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for Insulin Receptor

Target: Insulin Receptor (INSR)

Alternative Name: Insulin Receptor

Background: INSR is an insulin receptor type protein kinase. Binding of insulin to INSR stimulates glucose uptake. Two insulin receptor mRNA transcripts resulting from alternative splicing of exon 11 in the receptor gene are expressed in a highly regulated tissue-specific fashion. Mutations in the INSR gene contribute to diseases, including of various forms of insulin resistance, insulin-resistant diabetes mellitus, noninsulin-dependent diabetes mellitus (NIDDM), Rabson-Mendenhall syndrome and Leprechaunism (Donohue Syndrome).

Gene ID: 3643

UniProt: P06213

Pathways: NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity