ATM
Reactivity: Human
IF, DB
Host: Rabbit
Polyclonal
RB8121
unconjugated
Application Notes
ATM antibody can be used in ELISA starting at 1:200 - 1:1000, Western Blot starting at 1:100 - 1:300, immunocytochemistry starting at 1:75, and immunofluorescence starting at 1:25 - 1:50.
ATM-3E8 recognizes full-length ATM, a 370 kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation. The ATM gene product is a 370 kD nuclear phosphoprotein with C-terminal homology to phosphatidylinositol 3-kinase. ATM is involved in the induction of a DNA damage control pathway. Mutations in the ATM gene cause neuronal degeneration, gonadal abnormalities, and immune deficiencies as part of the hereditary disease ataxia telangiectasia.