HSP90B2P antibody (AA 289-300)

Catalog No. ABIN2470237

Product Details anti-HSP90B2P Antibody

Target: HSP90B2P (Heat Shock Protein 90kDa beta (Grp94), Member 2, Pseudogene (HSP90B2P))

Binding Specificity: AA 289-300

Reactivity: Human, Mouse, Rat, Chicken, Drosophila melanogaster, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSP90B2P antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Immunoaffinity Chromatography

Immunogen: HSP90B2P antibody was raised against amino acids 289-300 of HSP90B2P (Human).

Application Details

Application Notes: HSP90B2P antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 - 10 μg/mL, immunoprecipitation, and flow cytometry.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store HSP90B2P antibody at 4 °C or -20 °C.

Target Details for HSP90B2P

Target: HSP90B2P (Heat Shock Protein 90kDa beta (Grp94), Member 2, Pseudogene (HSP90B2P))

Alternative Name: HSP90B2P (HSP90B2P Products)

Synonyms: GRP94P1 antibody, GRP94b antibody, HSP antibody, HSPCP2 antibody, TRA1P1 antibody, TRAP1 antibody, heat shock protein 90 beta family member 2, pseudogene antibody, HSP90B2P antibody

Background: Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3.

Gene ID: 3320

UniProt: P07900