Integrin beta 2 antibody (Activation Site)

Catalog No. ABIN2478861

Cited in 3+ publications. The Mouse Monoclonal anti-Integrin beta 2 antibody (Clone MEM-148) (ABIN2478861) specifically detects Integrin beta 2 in FACS, WB and IP. The antibody is reactive with Human samples.

Quick Overview for Integrin beta 2 antibody (Activation Site) (ABIN2478861)

Target: Integrin beta 2 (ITGB2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP)

Clone: MEM-148

Product Details anti-Integrin beta 2 Antibody

Binding Specificity: Activation Site

Specificity: Specificity property: activation epitope

Characteristics: Purified IgG

Purification: Purified

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Preservative: Without preservative

References for anti-Integrin beta 2 antibody (ABIN2478861)

Feng, Zhang, Almulki, Faez, Whitford, Hafezi-Moghadam, Cross: "Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1." in: Journal of leukocyte biology, Vol. 90, Issue 2, pp. 313-21, (2011) (PubMed).

Luissint, Lutz, Calderwood, Couraud, Bourdoulous: "JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation." in: The Journal of cell biology, Vol. 183, Issue 6, pp. 1159-73, (2008) (PubMed).

Drbal, Angelisová, Hilgert, Cerný, Novák, Horejsí: "A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells." in: Blood, Vol. 98, Issue 5, pp. 1561-6, (2001) (PubMed).

Target Details for Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Alternative Name: CD18

Background: Synonyms: INTEGRIN BETA 2 CHAIN

Gene ID: 3689

UniProt: P05107

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation