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Calcineurin A antibody (AA 264-283) (FITC)

CAN Reactivity: Human WB, IP, IHC, ICC, IF Host: Rabbit Polyclonal FITC
Catalog No. ABIN2481985
  • Target See all Calcineurin A (CAN) Antibodies
    Calcineurin A (CAN)
    Binding Specificity
    • 11
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 264-283
    Reactivity
    • 27
    • 14
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 28
    • 2
    • 1
    Rabbit
    Clonality
    • 21
    • 9
    Polyclonal
    Conjugate
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Calcineurin A antibody is conjugated to FITC
    Application
    • 19
    • 13
    • 11
    • 11
    • 10
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    Detects ~61 kDa.
    Cross-Reactivity
    Dog, Human, Mouse, Rabbit, Rat
    Purification
    Peptide Affinity Purified
    Immunogen
    Human Calcineurin A peptide (AA 264-283)
    Top Product
    Discover our top product CAN Primary Antibody
  • Application Notes
    • WB (1:1000)
    • ICC/IF (1:120)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN2481985 was sufficient for detection of Calcineurin A in 20 μg of Heat shock Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    Calcineurin A (CAN)
    Alternative Name
    Calcineurin A (CAN Products)
    Synonyms
    Cna antibody, DDBDRAFT_0185021 antibody, DDBDRAFT_0217855 antibody, DDB_0185021 antibody, DDB_0217855 antibody, PPP3CC antibody, CAN A1/PP2B antibody, CG1455 antibody, CNA1 antibody, Can antibody, Cana1 antibody, CnA antibody, CnnA21EF antibody, D14 antibody, DmCanA1-100B antibody, Dmel\\CG1455 antibody, PP2B antibody, PP2B 21EF antibody, PpD14 antibody, canA antibody, pMY4 antibody, calcineurin A antibody, Calcineurin A antibody, CaM-dependent protein phosphatase, catalytic subunit antibody, protein phosphatase 3 catalytic subunit alpha antibody, Calcineurin A1 antibody, protein phosphatase 3 catalytic subunit beta antibody, Cna antibody, NFIA_077970 antibody, ACLA_011200 antibody, PAS_chr3_0414 antibody, canA antibody, PPP3CA antibody, CanA1 antibody, PPP3CB antibody
    Background
    Calcineurin is a heterodimeric phosphatase protein, also known as calcium-dependent serine-threonine phosphatase. The structure consists of a catalytic subunit alpha, Calcineurin A (57-59KDa) the active site and a Ca2+ binding unit, Calcineurin B (19-20KDa) the regulatory subunit(1). Calcineurin plays a key role in the T-cell response growth and differentiation mechanism, regulating the activation of the Nuclear factor of activated T-cells (NFATc) which are important in the expression of IL-2 genes. Calcineurin has been the target of inhibitors, the novel and structural immune-suppressants antifungal drugs(2). Genetic studies in yeast and fungi established the molecular basis of the inhibition mechanism by cyclosporine A and FK506 (3).
    Gene ID
    5530
    UniProt
    Q08209
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