Thyroperoxidase antibody (N-Term)

Catalog No. ABIN2500606

Product Details anti-Thyroperoxidase Antibody

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Horse, Pig, Rabbit, Saccharomyces cerevisiae, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thyroperoxidase antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GASNTALARW LPPVYEDGFS QPRGWNPGFL YNGFPLPPVR EVTRHVIQVS

Predicted Reactivity: Dog: 93%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 86%, Rat: 100%, Yeast: 83%

Characteristics: This is a rabbit polyclonal antibody against TPO. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human TPO

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Alternative Name: Thyroid Peroxidase (TPO Products)

Synonyms: MSA antibody, TDH2A antibody, TPX antibody, TPO antibody, msa antibody, tpx antibody, xtpo antibody, LOC100218312 antibody, thyroid peroxidase antibody, TPO antibody, Tpo antibody, tpo antibody, LOC100547103 antibody

Background: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
Protein Interaction Partner: DUOX1, TXNDC11,
Protein Size: 611

Molecular Weight: 67 kDa

Gene ID: 7173

Pathways: Thyroid Hormone Synthesis