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DDIT3 antibody (pSer30)
DDIT3
Reactivity: Human, Mouse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-DDIT3 Antibody
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Target
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DDIT3
(DNA-Damage-Inducible Transcript 3 (DDIT3))
Binding Specificity
All epitopes for DDIT3 antibodies
pSer30
Reactivity
All reactivities for DDIT3 antibodies
Human, Mouse
Host
All hosts for DDIT3 antibodies
Rabbit
Clonality
All clonalities for DDIT3 antibodies
Polyclonal
Conjugate
All conjugates for DDIT3 antibodies
This DDIT3 antibody is un-conjugated
Application
All applications for DDIT3 antibodies
Western Blotting (WB)
Specificity
The antibody detects endogenous level of CHOP only when phosphorylated at serine 30.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
CHOP (phospho Ser30) antibody was raised against a peptide sequence around phosphorylation site of serine30 (V-L-S (p)-S-D) derived from Human CHOP .
Isotype
IgG
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Application Details
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Application Notes
Western Blot: 1:500~1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for DDIT3
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Target
DDIT3
(DNA-Damage-Inducible Transcript 3 (DDIT3))
Alternative Name
CHOP (DDIT3 Products )
Synonyms
chop antibody, Xchop antibody, cebpz antibody, chop10 antibody, gadd153 antibody, CHOP-10 antibody, CHOP10 antibody, CHOP antibody, Chop10 antibody, Gadd153 antibody, CEBPZ antibody, GADD153 antibody, DNA damage inducible transcript 3 antibody, DNA-damage inducible transcript 3 antibody, DNA damage inducible transcript 3 L homeolog antibody, ddit3 antibody, Ddit3 antibody, DDIT3 antibody, ddit3.L antibody
Background
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.
Molecular Weight
19 kDa
Gene ID
1649
NCBI Accession
NP_001181982
UniProt
P35638
Pathways
Regulation of Muscle Cell Differentiation , ER-Nucleus Signaling , Skeletal Muscle Fiber Development , Cell RedoxHomeostasis
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