FGFR1/FGFR2 antibody (pTyr463, pTyr466)

Catalog No. ABIN2568142

Product Details anti-FGFR1/FGFR2 Antibody

Target: FGFR1/FGFR2 (FGFR1, FGFR2)

Binding Specificity: pTyr463, pTyr466

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR1/FGFR2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: The antibody detects endogenous levels of FGFR1/2 only when phosphorylated at tyrosine 463/466.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: FGFR1/2 (phospho Tyr463/466) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 463/466 (S-E-Y (p)-E-L) derived from Human FGFR1/2.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for FGFR1/FGFR2

Target: FGFR1/FGFR2 (FGFR1, FGFR2)

Alternative Name: FGFR1/2 (FGFR1/FGFR2 Products)

Background: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

Molecular Weight: 91 kDa

Gene ID: 2260, 2263

NCBI Accession: NP_075598

UniProt: P11362, P21802