The antibody detects endogenous levels of Histamine H1 Receptor only when phosphorylated at serine 398.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
Histamine H1 Receptor (phospho Ser398) antibody was raised against a peptide sequence around phosphorylation site of Serine 398 (S-H-S (p)-R-Q) derived from Human Histamine H1 Receptor .
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.