IKK-alpha /IKK-beta antibody (pSer180, pSer181)
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- Target See all IKK-alpha /IKK-beta products
- IKK-alpha /IKK-beta
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Binding Specificity
- pSer180, pSer181
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Reactivity
- Mouse, Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This IKK-alpha /IKK-beta antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- The antibody detects endogenous level of IKK- alpha/beta only when phosphorylated at serine 180/181.
- Purification
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- Immunogen
- IKK- alpha/ beta (phospho Ser180/181) antibody was raised against a peptide sequence around phosphorylation site of serine 180/181 (C-T-S (p)-F-V) derived from Human IKK- alpha/ beta.
- Isotype
- IgG
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- Application Notes
- Western Blot: 1:500~1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store antibody at -20°C for up to one year.
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- Target
- IKK-alpha /IKK-beta
- Alternative Name
- IKK alpha/ beta (IKK-alpha /IKK-beta Products)
- Background
- Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.
- Molecular Weight
- 85 kDa
- Gene ID
- 1147
- NCBI Accession
- NP_001269
- UniProt
- O15111, O14920
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