CD1a antibody

Catalog No. ABIN2618409

Product Details anti-CD1a Antibody

Target: CD1a

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD1a antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Specificity: The CBT6 antibody is directed against human CD1a and has been reported to cross react with mouse thymocytes.

Purification: Purified

Immunogen: CBT6 is a mouse monoclonal IgG1 antibody derived by the fusion of NS0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a T-lymphocyte derived antigen.

Type of Immunogen: Cells

Clone: CBT6

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA, Flo, ICC, IHC, IHC-Fr

Usage: CD1 Molecules are 49kD type 1 membrane glycoproteins that contain a single Ig-like domain, which associate with beta-2 microglobulin to form a heterodimer. The CD1 glycoproteins function as antigen-presenting molecules for exogenous and endogenous lipids, glycolipids and lipopeptides to specialized T cells. The CD1 Molecules show some sequence similarities to major histocompatibility (MHC) class I and class II molecules, but are not encoded by the MHC genes and are not significantly polymorphic. In humans, the CD1 genes encode five isoforms of CD1, namely CD1a-e, with each type reported to show a different pattern of expression on cells and within different tissues. CD1a, b and c belong to group 1 of the CD1 family and are expressed by dendritic cells, activated monocytes and other antigen-presenting cells. CD1a is also expressed by some malignancies of T cell lineage and is commonly used as a marker of dendritic cell populations.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 50 % glycerol, 0.2 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for CD1a

Target: CD1a

Alternative Name: CD1A (CD1a Products)

Synonyms: CD1 antibody, FCB6 antibody, HTA1 antibody, R4 antibody, T6 antibody, CD1A antibody, CD1a molecule antibody, CD1 antigen antibody, T-cell surface glycoprotein CD1a antibody, CD1A antibody, CD1.1 antibody, LOC100156095 antibody, LOC101111409 antibody

Background: Name/Gene ID: CD1A

Synonyms: CD1A, CD1, CD1A antigen, a polypeptide, CD1a molecule, FCB6, HTA1, HTa1 thymocyte antigen, R4, T6, CD1a antigen, Cluster of differentiation 1 A

Gene ID: 909

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process