May be used in immunoassays to detect and quantitate pancreatic trypsin. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0.9mg/mL (OD280nm)
Buffer
PBS, pH 7.4
Storage
-20 °C
Storage Comment
Store the antibody at -20 °C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Trypsin is a 24 kDa enzyme of the serine proteinase family. It is produced in the pancreas as an inactive precursor, trypsinogen, but the active enzyme is located in the gastrointestinal tract where it degrades proteins to large peptides. Trypsin prefers lysine and arginine residues. One of the substrates for trypsin is chymotrypsinogen which is cleaved to produce active chymotrypsin. High levels of immunoreactive trypsin in the bloodstream can indicate pancreatic malfunction and this indicator is used to screen for and diagnose Cystic Fibrosis.Synonyms: Beta-trypsin, Cationic trypsinogen, Serine protease 1, TRP1, TRY1, TRYP1, Trypsin I