CHEK1 antibody (AA 1-474)
Quick Overview for CHEK1 antibody (AA 1-474) (ABIN264916)
Target
See all CHEK1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 1-474
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Specificity
- This antibody recognizes CHK1 kinase.
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Purification
- Purified
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Immunogen
- A GST fusion protein corresponding to amino acid sequence 1-474 with having a molecular weight of 54 kD.
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Isotype
- IgG
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anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer296) antibodyCHEK1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer286) antibodyCHEK1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer301) antibodyCHEK1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer345) antibodyCHEK1 Reactivity: Human WB, IF, ICC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (Middle Region) antibodyCHEK1 Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibodyCHEK1 Reactivity: Human WB, IHC (p), DB Host: Rabbit Polyclonal RB7845-RB18425 unconjugated
anti-Checkpoint Kinase 1 (CHEK1) antibodyCHEK1 Reactivity: Human, Mouse WB, ELISA Host: Mouse Monoclonal 2G1D5 unconjugated
anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibodyCHEK1 Reactivity: Mouse, Chicken ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 1 (CHEK1) antibodyCHEK1 Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Monoclonal 2F2 unconjugated Recombinant Antibody
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Application Notes
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Western Blot: 1-10 μg/mL. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Buffer
- Phosphate buffered saline with 0.08 % Sodium Azide as preservative.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freezing and thawing.
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Storage
- -20 °C
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- CHEK1 (Checkpoint Kinase 1 (CHEK1))
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Alternative Name
- CHK1
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Background
- One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry in to mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk 1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2.Synonyms: CHEK-1, CHEK1, CHK1 checkpoint homolog, Serine/threonine-protein kinase Chk1
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Gene ID
- 1111
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NCBI Accession
- NP_001107593
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UniProt
- O14757
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Pathways
- p53 Signaling, Apoptosis, Cell Division Cycle, DNA Damage Repair
Target
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