Stargazin antibody

Catalog No. ABIN265040

Product Details anti-Stargazin Antibody

Target: Stargazin (CACNG2) (Calcium Channel, Voltage-Dependent, gamma Subunit 2 (CACNG2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Stargazin antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to CACNG2.

Purification: Purified

Immunogen: Synthetic peptide derived from the rat calcium channel gamma2 subunit conjugated to KLH

Isotype: IgG

Application Details

Application Notes: Western Blot: 5 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for Stargazin

Target: Stargazin (CACNG2) (Calcium Channel, Voltage-Dependent, gamma Subunit 2 (CACNG2))

Alternative Name: CACNG2 (CACNG2 Products)

Synonyms: cacng2 antibody, zgc:64200 antibody, CACNG2 antibody, stargazin antibody, AW060990 antibody, B230105C07Rik antibody, B930041E13Rik antibody, stargazer antibody, stg antibody, wag antibody, waggler antibody, Ipr328 antibody, MRD10 antibody, calcium voltage-gated channel auxiliary subunit gamma 2 antibody, calcium channel, voltage-dependent, gamma subunit 2a antibody, calcium channel, voltage-dependent, gamma subunit 2 antibody, CACNG2 antibody, cacng2a antibody, cacng2 antibody, Cacng2 antibody

Background: Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits alpha1, alpha2/delta, beta in a 1:1:1 stoichiometry. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the alpha1 subunits contain the ion channel pore while the auxiliary alpha2/delta and beta subunits confer optimal cell surface expression and channel kinetics1. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the alpha1, alpha2/delta, beta core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed gamma 1. Upon co-expression with the alpha1.1, alpha2/delta1, beta1a subunits of the skeletal muscle VDCC, gamma subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel2. Together, these results suggest that gamma subunits modulate skeletal muscle VDCCs by stabilising their conformation. The gamma 2 subunits, or stargazin, the product of a gene mutated in the stargazer mouse, is a homolog of the gamma 1 channel and is selectively expressed in the brain. It is considered to be a putative neuronal Ca2+ channel subtype mainly based on its homology to the gamma 1.Synonyms: Neuronal voltage-gated calcium channel gamma-2 subunit, TARP gamma-2, Transmembrane AMPAR regulatory protein gamma-2, Voltage-dependent calcium channel gamma-2 subunit

Gene ID: 10369

NCBI Accession: NP_006069

UniProt: Q9Y698

Pathways: Skeletal Muscle Fiber Development