CACNG4 antibody

Catalog No. ABIN265042

Product Details anti-CACNG4 Antibody

Target: CACNG4 (Calcium Channel, Voltage-Dependent, gamma Subunit 4 (CACNG4))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNG4 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to CACNG4.

Purification: Purified

Immunogen: Synthetic peptide derived from the rat calcium channel gamma4 subunit conjugated to KLH

Isotype: IgG

Application Details

Application Notes: Western Blot: 5- 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for CACNG4

Target: CACNG4 (Calcium Channel, Voltage-Dependent, gamma Subunit 4 (CACNG4))

Alternative Name: CACNG4 (CACNG4 Products)

Synonyms: CACNG4 antibody, AI413107 antibody, AW491861 antibody, calcium voltage-gated channel auxiliary subunit gamma 4 antibody, calcium channel, voltage-dependent, gamma subunit 4 antibody, CACNG4 antibody, Cacng4 antibody

Background: Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits alpha1, alpha2/delta, beta in a 1:1:1 stoichiometry1. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the alpha1 subunits contain the ion channel pore while the auxiliary alpha2/delta and beta subunits confer optimal cell surface expression and channel kinetics. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the alpha1, alpha2/delta, beta core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed gamma 1. Upon co-expression with the alpha1.1, alpha2/delta1, beta1a subunits of the skeletal muscle VDCC, gamma subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel. Together, these results suggest that gamma subunits modulate skeletal muscle VDCCs by stabilising their conformation. The gamma 4 subunit is specifically localized in the brain, with the gamma 2 and gamma 3 subunits. It shares >60 % sequence homology with the gamma 2 and gamma 3 subunits and ~25 % sequence homology with the gamma 1 and gamma 5 subunits.Synonyms: Neuronal voltage-gated calcium channel gamma-4 subunit, Voltage-dependent calcium channel gamma-4 subunit

Gene ID: 27092

NCBI Accession: NP_055220

UniProt: Q9UBN1