FBXW7 antibody

Catalog No. ABIN265230

The Rabbit Polyclonal anti-FBXW7 antibody (ABIN265230) specifically detects FBXW7 in WB. The antibody is reactive with Human samples.

Quick Overview for FBXW7 antibody (ABIN265230)

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXW7 Antibody

Specificity: This antibody detects FBXW7, widely expressed in most tissues.

Purification: Purified

Immunogen: Synthetic peptide dervied from the human FBXW7 protein

Application Details

Application Notes: Western Blot (1-5 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Target Details for FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Alternative Name: FBXW7

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.Synonyms: Archipelago homolog, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW7, FBX30, SEL-10, SEL10, hAgo, hCDC4

Gene ID: 55294

NCBI Accession: NP_001013433

UniProt: Q969H0

Pathways: Notch Signaling, EGFR Signaling Pathway